PUBLICATIONS
Robert M.
Williams, Colorado State University
1. º A stereoselective Synthesis of
Partially Substituted 1,2,3-Butatriene Derivatives via Hydroboration, Yoshida, T.; Williams,
R.M.; Negishi, E-i., J. Am. Chem. Soc., 1974, 96, 3688-3690.
2. º A Stereoselective Synthesis of
cis-Alkenylboranes,
Negishi, E-i.; Williams, R.M.; Lew, G.; Yoshida, T., J. Organomet. Chem., 1975, 92, C4-C6.
3. ¦ An Efficient Synthesis of
d,l-Gliovictin: Construction of the Hydroxymethyl Moiety via a
3-Formyl-2,5-Piperazinedione, Williams, R.M.; Rastetter, W.H., Tetrahedron
Lett., 1979, 1187-1190.
4. ¦ Synthesis of the Fungal Metabolites
(±)-Gliovictin and (±)-Hyalodendrin, Williams, R.M.; Rastetter, W.H., J. Org.
Chem., 1980, 45, 2625-2631.
5. ¤ Asymmetric Total Synthesis of
Erythromycin I,
Woodward, R.B.; Logusch, E.; Nambiar, K.P.; Sakan, K.; Ward, D.E.; Au-Yeung,
B.W.; Balaram, P.; Browne, L.J.; Card, P.J.; Chen, C.H.; Chenevert, R.B.;
Fliri, A.; Frobel, K.; Gais, H.J.; Garratt, D.G.; Hayakawa, K.; Heggie, W.;
Hesson, D.P.; Hoppe, D.; Hoppe, I.; Hyatt, J.A.; Ikeda, D.; Jacobi, P.A.; Kim,
K.S.; Kobuke, Y.; Kojima, K.; Krowicki, K.; Lee, V.J.; Leubert, T.; Malchenko,
S.; Martens, J.; Mathews, R.S.; Ong, B.S.; Press, J.B.; RajanBabu, T.V.;
Rousseau, G.; Sauter, H.M.; Suzuki, M.; Tatsuta, K.; Tolbert, L.M.; Truesdale,
E.A.; Uchida, I.; Ueda, Y.; Uyehara, T.; Vasella, A.T.; Vladuchick, W.C.; Wade,
P.A.; Williams, R.M.; Wong, H.N.-C. J. Am. Chem. Soc., 1981, 103, 3210-3213.
6. ¤ Asymmetric Total Synthesis of
Erythromycin II,
Woodward, R.B.; Logusch, E.; Nambiar, K.P.; Sakan, K.; Ward, D.E.; Au-Yeung,
B.W.; Balaram, P.; Browne, L.J.; Card, P.J.; Chen, C.H.; Chenevert, A.; Fliri,
A.; Frobel, K.; Gais, H.J.; Garratt, D.G.; Hayakawa, K.; Heggie, W.; Hesson,
D.P.; Hoppe, D.; Hoppe, I.; Hyatt, J.A.; Ikeda, D.; Jacobi, P.A.; Kim, K.S.;
Kobuke, Y.; Kojima, K.; Krowicki, K.; Lee, V.J.; Leubert, T.; Malchenko, S.;
Martens, J.; Mathews, R.S.; Ong, B.S.; Press, J.B.; RajanBabu, T.V.; Rousseau,
G.; Sauter, H.M.; Suzuki, M.; Tatsuta, K.; Tolbert, L.M.; Truesdale, E.A.;
Uchida, I.; Ueda, Y.; Uyehara, T.; Vasella, A.T.; Vladuchick, W.C.; Wade, P.A.;
Williams, R.M.; Wong, H.N.-C., J. Am. Chem. Soc., 1981, 103, 3213-3215.
7. ¤ Asymmetric Total Synthesis of
Erythromycin III,
Woodward, R.B.; Logusch, E.; Nambiar, K.P.; Sakan, K.; Ward, D.E.; Au-Yeung,
B.W.; Balaram, P.; Browne, L.J.; Card, P.J.; Chen, C.H.; Chenevert, R.B.;
Fliri, A.; Frobel, K.; Gais, H.J.; Garratt, D.G.; Hayakawa, K.; Heggie, W.;
Hesson, D.P.; Hoppe, D.; Hoppe, I.; Hyatt, J.A.; Ikeda, D.; Jacobi, P.A.; Kim,
K.S.; Kobuke, Y.; Kojima, K.; Krowicki, K.; Lee, V.J.; Leubert, T.; Malchenko,
S.; Martens, J.; Mathews, R.S.; Ong, B.S.; Press, J.B.; RajanBabu, T.V.;
Rousseau, G.; Sauter, H.M.; Suzuki, M.; Tatsuta, K.; Tolbert, L.M.; Truesdale,
E.A.; Uchida, I.; Ueda, Y.; Uyehara, T.; Vasella, A.T.; Vladuchick, W.C.; Wade,
P.A.; Williams, R.M.; Wong, H.N.-C., J. Am. Chem. Soc., 1981, 103, 3215-3217.
º Syracuse University
¦
MIT
¤ Harvard University
*Colorado
State University
1981
8. *Bicyclomycin
Synthetic Studies: Utilization of
Bridgehead Carbanions,
Williams, R. M., Tetrahedron Lett., 1981, 22, 2341-2344.
1982
9. *A
New and Efficient Cyclization Reaction to Construct the Bicyclomycin Ring
System: Synthesis of N,NÕ-Dimethyl-4-des-methylene Bicyclomycin, Williams, R.M.;
Anderson, O.P.; Armstrong, R.; Josey, J.; Meyers, H.; Eriksson, C., J. Am.
Chem. Soc.,
1982,
104,
6092-6099.
1983
10. *C-Glycosidation
of Pyridyl Thioglycosides, Williams, R.M.; Stewart, A.O., Tetrahedron Lett., 1983, 24, 2715-2718.
11. *Regioselective
Functionalization of Bicyclic Piperazinedione Bridgehead Carbanions, Williams, R.M.; Dung,
J-S.; Josey, J.; Armstrong, R.W.; Meyers, H., J. Am. Chem. Soc., 1983, 105, 3214-3220.
12. *Improved
Synthesis and Absolute Configuration of (+)- and
(-)-2,2,4-Trimethyl-1,3-dioxolane-4-carboxaldehyde, Dung, J-S.; Armstrong,
R.W.; Anderson, O.P.; Williams, R.M., J. Org. Chem., 1983, 48, 3592-3594.
1984
13. *Metal-Mediated
Concomitant Silyl Ether Cleavage/Cyclization Reactions to Construct Bicyclic
Piperazinediones and a New Polymer-Supported Hg(II) Perchlorate, Dung, J-S.; Armstrong,
R.W.; Williams, R.M., J. Org. Chem., 1984, 49, 3416-3419.
14. *Alternate
Preparation of Methyl-3-amino-2,3,6-trideoxy-a-D-arabino-hexopyranoside and Chiral Intermediates
for the Synthesis of Thienamycin, Stewart, A.O.; Williams, R.M., Carbohydrate
Res., 1984, 135, 167-173.
15. *Stereocontrolled
Total Synthesis of (±)- and (+)-Bicyclomycin: New Carbon-Carbon Bond-Forming
Reactions on Electrophilic Glycine Anhydride Derivatives, Williams, R.M.;
Armstrong, R.W.; Dung, J-S., J. Am. Chem. Soc., 1984, 106, 5748-5750.
1985
16. *Synthesis
and Antimicrobial Evaluation of Bicyclomycin Analogs, Williams, R.M.;
Armstrong, R.W.; Dung, J-S., J. Med. Chem., 1985, 28, 733-740.
17. *Unusual
Bridgehead Hydroxylations via Selenoxides: Evidence for Bridgehead Carbocations, Williams, R.M.; Dung,
J-S., Tetrahedron Lett., 1985, 26, 37-38.
18. *A
Divergent Generalized Synthesis of Unsymmetrically Substituted
2,5-Piperazinediones,
Williams, R.M.; Armstrong, R.W.; Maruyama, L.K.; Dung, J-S.; Anderson, O.P., J.
Am. Chem. Soc.,
1985,
107,
3246-3253.
19. *Stereocontrolled
Total Synthesis of (±)- and (+)-Bicyclomycin, Williams, R.M.; Armstrong, R.W.; Dung,
J-S., J. Am. Chem. Soc., 1985, 107, 3253-3266.
20. *C-Glycosidation
of Pyridyl Thioglycosides, Stewart, A.O.; Williams, R.M., J. Am. Chem. Soc., 1985, 107, 4289-4296.
21. *Thiolate
Additions to Bicyclomycin and Analogues: A Structurally Novel Latent
Michael-Acceptor System, Williams, R.M.; Tomizawa, K.; Armstrong, R.W.; Dung, J-S.,
J. Am. Chem. Soc.,
1985,
107,
6419-6421.
1986
22. *Electrophilic
Glycinates: New and Versatile Templates for Asymmetric Amino Acid Synthesis, Sinclair, P.J.; Zhai,
D.; Reibenspies, J.; Williams, R.M., J. Am. Chem. Soc., 1986, 108, 1103-1104.
23. *Promising
Cyclization Reactions to Construct the Ring Systems of Brevianamides A,B, Williams, R.M.;
Glinka, T., Tetrahedron Lett., 1986, 27, 3581-3584.
24. *Asymmetric
Synthesis of (R)- and (S)-[2-2H1]-Glycine, Williams, R.M.; Zhai,
D.; Sinclair, P.J., J. Org. Chem., 1986, 51, 5021-5022.
25. *Synthesis
of a Bicyclo[4.1.1] b-Lactam: A Novel,
Anti-Bredt b-Lactam, Williams, R.M.; Lee,
B., J. Am. Chem. Soc., 1986, 108, 6431-6433.
1987
26. *A
New Synthetic Approach to
1-Hydroxymethyl-8-methoxy-1,2,3,4-tetrahydro-isoquinolin-4-one, Williams, R.M.; Zhai,
W.; Ehrlich, P.P.; Hendrix, J., J. Org. Chem., 1987, 52, 2615-2617.
27. *Mechanism,
Biological Relevance and Structural Requirements for Thiolate Additions to
Bicyclomycin and Analogues: A Unique Latent Michael Acceptor System, Williams, R.M.;
Tomizawa, K.; Armstrong, R.W.; Dung, J-S., J. Am. Chem. Soc., 1987, 109, 4028-4035.
28. *Synthesis
of Functionalized Bicyclic Dioxopiperazines via Intramolecular Epoxide Opening, Williams, R.M.;
Maruyama, L.K., J. Org. Chem., 1987, 52, 4044-4047.
1988
29. *Alkynylation
of Mixed Haloacetals with Organotin Acetylides, Zhai, D.; Zhai, W.;
Williams, R.M., J. Am. Chem. Soc., 1988, 110, 2501-2505.
30. *Practical
Asymmetric Synthesis of a-Amino
Acids through Carbon-Carbon Bond Constructions on Electrophilic Glycine
Templates,
Williams, R.M.; Sinclair, P.J.; Zhai, D.; Chen, D., J. Am. Chem. Soc., 1988, 110, 1547-1557.
31. *Bicyclomycin:
Synthetic, Mechanistic and Biological Studies, Williams, R.M.; Durham, C.A., Chemical
Reviews,
1988,
88,
511-540.
32. *Asymmetric
Synthesis of b-Carboxy Aspartic
Acid (Asa),
Williams, R.M.; Sinclair, P.J.; Zhai, W., J. Am. Chem. Soc., 1988, 110, 482-483.
33. *Synthesis
of Verruculotoxin,
Williams, R.M.; Brunner, E.J.; Sabol, M.R., Synthesis, 1988, 963-966.
34. *Versatile
New Approach to the Synthesis of Monosubstituted and Bicyclic
Piperazine-2,5-diones: Unusual in situ Generation
and Enolate Addition to a Cumulene, Williams, R.M.; Kwast, A., J. Org. Chem., 1988, 53, 5785-5787.
35. *Asymmetric
Synthesis of a-Amino Acids:
Comparison of Enolate vs Cation Functionalization of
N-BOC-5,6-Diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones, Williams, R.M.; Im,
M-N., Tetrahedron Lett., 1988, 29, 6075-6078.
36. *Versatile,
stereocontrolled, Asymmetric Synthesis of E-Vinylglycine Derivatives, Williams, R.M.; Zhai,
W., Tetrahedron,
1988,
44, 5425-5430.
37. *Facial
Selectivity of the Intramolecular SN2Õ
Cyclization: Stereocontrolled Total Synthesis of Brevianamide B, Williams, R.M.;
Glinka, T.; Kwast, E., J. Am. Chem. Soc., 1988, 110, 5927-5929.
38. *Synthesis
and X-Ray Crystal Structure Determination of 1,3-Bridged b-Lactams: Novel,
Anti-Bredt b-Lactams, Williams, R.M.; Lee,
B-H.; Miller, M.M.; Anderson, O.P., in Recent Advances in the Chemistry of b-Lactam Antibiotics, Royal Society of
Chemistry, London 1988 pp. 106-118.
1989
39. *Synthesis
and X-Ray Crystal Structure Determination of 1,3-Bridged b-Lactams: Novel,
Anti-Bredt b-Lactams, Williams, R.M.; Lee,
B.H.; Miller, S.; Anderson, O.P., J. Am. Chem. Soc., 1989, 111, 1073-1081.
40. *Carbanion-Mediated
Oxidative Deprotection of Non-Enolizable Benzylated Amides, Williams, R.M.; Kwast,
E., Tetrahedron Lett., 1989, 30, 451-454.
41. *Remarkable,
Enantio-Divergent Biogenesis of Brevianamide A and B, Williams, R.M.; Kwast,
E.; Coffman, H.; Glinka, T., J. Am. Chem. Soc., 1989, 111, 3064-3065.
42. *Synthetic
studies on FR900482: Promising Method to Construct the Bicyclic Hydroxylamine
Hemi-Ketal Ring System, Yasuda, N.; Williams, R.M., Tetrahedron Lett., 1989, 30, 3397-3400.
43. *Synthetic
Studies on Paraherquamide: Regioselectivity of Indole Oxidation, Williams, R.M.; Glinka,
T.; Kwast, E., Tetrahedron Lett., 1989, 30, 5575-5578.
44. *Synthesis
of Optically Active a-Amino Acids, Williams, R.M.,
Pergamon Press, 1989, Oxford, (Organic Chemistry Series, Baldwin, J.E., Series
Editor). 410 pp.
1990
45. *Synthesis
of Ethynylglycine (FR900130), Williams, R.M.;Aldous, D.J.; Aldous, S.C., J.
Chem. Soc.
Perkin Trans I Comm., 1990, 171-172.
46. *Asymmetric
Synthesis of Arylglycines, Williams, R.M.; Hendrix, J.A., J. Org. Chem., 1990, 55, 3723-3728.
47. *Asymmetric,
Stereocontrolled Total Synthesis of (-)-Brevianamide B, Williams, R.M.;
Glinka, T.; Kwast, E.; Coffman, H.; Stille, J.K., J. Am. Chem. Soc., 1990, 112, 808-821.
48. *General
Synthesis of b,g-Alkynylglycine
Derivatives,
Williams, R.M.; Aldous, D.J.; Aldous, S.C., J. Org. Chem., 1990, 55, 4657-4663.
49. *Synthetic
Studies on Aspirochlorine (A30641), Williams, R.M.; Miknis, G.F., Tetrahedron
Lett., 1990, 31, 4297-4300.
50. *Synthetic
Studies on Paraherquamide: Synthesis of the 2H-1,5-Benzodioxepin Ring System, Williams, R.M.;
Cushing, T.D., Tetrahedron Lett., 1990, 31, 6325-6328.
51. *Identification
of a Novel Structural Class of Positive Modulators of the N-Methyl-D-Aspartate
Receptor, Whose Actions are Mediated Through the Glycine Recognition Site, Monahan, J.B.; Hood,
W.F.; Compton, R.P.; Cordi, A.A.; Williams, R.M., Eur. J. Pharmacol., 1990, 189, 373-379.
1991
52. º Highly Stereoselective Synthesis of
Conjugated E,E- and E,Z-Dienes, E-Enynes and E-1,2,3-Butatrienes via
Alkenylborane Derivatives, Negishi, E.; Yoshida, T.; Abramovitch, A.; Lew, G.;
Williams, R.M., Tetrahedron, 1991, 47, 343-356.
53. *Synthesis,
Conformation, Crystal Structures and DNA Cleavage Abilities of Tetracyclic
Analogs of Quinocarcin, Williams, R.M.; Glinka, T.; Gallegos, R.; Ehrlich, P.;
Flanagan, M.E.; Coffman, H.; Park, G., Tetrahedron (Symposium-in-Print), 1991, 47, 2629-2642.
54. *Synthesis
of Tri-Substituted Furans: Mild Ti(IV)-Mediated Couplings to Acetals.
Construction of the Epoxy Hemi-Amido Ketal of Fusarin C, Williams, R.M.;
Esslinger, C.S., Tetrahedron Lett., 1991, 32, 3635-3638.
55. *Novel
Ring Contractions via 2,3-Wittig Rearrangements: Synthesis of
(2-Desoxy)-2-Methylene Bicyclomycin, Williams, R.M.; Sabol, M.R.; Kim, H.; Kwast,
A., J. Am. Chem. Soc., 1991, 113, 6621-6633.
56. *Asymmetric
Synthesis of 2,6-Diamino-6-hydroxymethylpimelic Acid: Assignment of
Stereochemistry,
Williams, R.M.; Im, M-N.; Cao, J., J. Am. Chem. Soc., 1991, 113, 6976-6981.
57. *Asymmetric
Synthesis of 1-Aminocyclopropane Carboxylic Acid Derivatives, Williams, R.M.;
Fegley, G.J., J. Am. Chem. Soc., 1991, 113, 8796-8806.
58. *Asymmetric
Synthesis of Mono-Substituted and a,a-Disubstituted a-Amino Acids via Diastereoselective Glycine Enolate
Alkylations,
Williams, R.M.; Im, M-N., J. Am. Chem. Soc., 1991, 113, 9276-9286.
59. *Cannizzaro-Based
O2-Dependent Cleavage of DNA by Quinocarcin, Williams, R.M.; Glinka,
T.; Flanagan, M.E.; Gallegos, R.; Coffman, H.; Pei, D., Advances in New Drug
Development,
The Pharmaceutical Society of Korea, Seoul 1991, 38-50.
1992
60. *Cannizzaro-Based
O2-Dependent Cleavage of DNA by
Quinocarcin,
Williams, R.M.; Glinka, T.; Flanagan, M.E.; Gallegos, R.; Coffman, H.; Pei, D.,
J. Am. Chem. Soc., 1992, 114, 733-740.
61. *Asymmetric
Synthesis of a-Amino Acids, Williams, R.M., Aldrichimica
Acta, 1992, 25, 11-25.
62. *Preparation
of 4-Methoxy-4Õ-nitrobiphenyl, Stille, J.K.; Echavarren, A.M.; Williams, R.M.;
Hendrix, J.A., Org. Synth., 1992, 71, 97-106.
63. *Asymmetric
Synthesis of Arylglycines, Williams, R.M.; Hendrix, J.A., Chem. Rev., 1992, 92, 889-917.
64. *DNA
Cross-Linking Studies on FR-900482: Observations on the Mode of Activation, Williams, R.M.;
Rajski, S.R., Tetrahedron Lett., 1992, 33, 2929-2932.
65. *Asymmetric
Synthesis of 2,6-Diaminopimelic Acids, Williams, R.M.; Yuan, C., J. Org. Chem., 1992, 57, 6519-6527.
66. *Asymmetric
Synthesis of S-(-)-Cucurbitine, Williams, R.M.; Fegley, G.J., Tetrahedron
Lett., 1992, 33, 6755-6758.
67. *Asymmetric
[1,3]-Dipolar Cycloaddition Reactions: Synthesis of Highly Substituted Proline
Derivatives,
Williams, R.M.; Zhai, W.; Aldous, D.J.; Aldous, S.C., J. Org. Chem., 1992, 57, 6527-6532.
68. *Design
and Synthesis of Biologically Active Peptide Mimics, Williams, R.M., The
Development and Utilization of Biologically Active Peptides, Technomic Publishing
Co., Lancaster, PA 1992, p. 187-215.
1993
69. *Total
Synthesis of Aspirochlorine, Williams, R.M.; Miknis, G.F., J. Am. Chem. Soc., 1993, 115, 536-547.
70. *Biosynthesis
of the Brevianamides: Quest for a Biosynthetic Diels-Alder Cyclization, Sanz-Cervera, J.-F.;
Glinka, T.; Williams, R.M., J. Am. Chem. Soc., 1993, 115, 347-348.
71. *Biosynthesis
of Brevianamides A and B: In Search of the Biosynthetic Diels-Alder
Construction,
Sanz-Cervera, J.F.; Glinka, T.; Williams, R.M., Tetrahedron, 1993, 49, 8471-8482.
72. *Determination
of DNA Cross-Linking Sequence Specificity of FR66979: Observations on the Mode
of Action of the FR900482 Class of Anti-tumor Compounds, Williams, R.M.;
Rajski, S.R., Tetrahedron Lett., 1993, 44, 7023-7026.
73. *Stereocontrolled
Total Synthesis of (+)-Paraherquamide B, Cushing, T.D.; Sanz-Cervera, J.F.; Williams,
R.M., J. Am. Chem. Soc., 1993, 115, 9323-9324.
74. *Asymmetric
Synthesis of 1S,2R-(+)-2-Phenyl-1-Aminocyclopropane-1-Carboxylic Acid, Williams, R.M.;
Fegley, G.J., J. Org. Chem., 1993, 58, 6933-6935.
75. *Stereoselective
Synthetic and Mechanistic Chemistry of Bicyclomycin, Williams, R.M., Studies
in Natural Products Chemistry, Atta-ur-Rahman, Editor, Elsevier Pub., 1993,
Amsterdam, Vol. 12.
76. *Vinyl
Glycine Derivatives for Memory and Learning Enhancement or Treatment of a
Cognitive Disorder,
Cordi, A.A.; Monahan, J.B.; Williams, R.M., U.S. Patent No. 5,208,260, May 4, 1993.
1994
77. *O2-Dependent Cleavage of DNA by
Tetrazomine,
Williams, R.M.; Flanagan, M.E.; Tippie, T., Biochemistry, 1994, 33, 4086-4092.
78. *Asymmetric
Synthesis of g-D(L)-Glutamyl-L-meso-Diaminopimelic
Acid Dipeptide,
Williams, R.M.; Yuan, C., J. Org. Chem., 1994, 59, 6190-6193.
79. *A
New Method for Hydroxymethylene Peptide Isostere Synthesis: Asymmetric
Synthesis of Statine,
Williams, R.M.; Colson, P-J.; Zhai, W., Tetrahedron Lett., 1994, 35, 9371-9374.
80. *FR66979
Requires Reductive Activation to Cross-Link DNA Efficiently, Huang, H.; Rajski,
S.R.; Williams, R.M.; Hopkins, P.B., Tetrahedron Lett., 1994, 35, 9669-9672.
1995
81. *Netropsin
and Spermine Conjugates of a Water-Soluble Quinocarcin Analog: Analysis of
Sequence-Specific DNA Interactions, Flanagan, M.E.; Rollins, S.B.; Williams, R.M.,
Chem. Biol.,
1995,
2,
147-156.
82. *Asymmetric
Synthesis of a-Amino Acids, Williams, R.M., Advances
in Asymmetric Synthesis, JAI Press 1995, Volume 1 (pp 45-94) A. Hassner, Ed.
83. *Studies
on the Biosynthesis of Taxol: Total Synthesis of Taxa-4(20),11(12)-diene and
Taxa-4(5),11(12)-diene. The First Committed Biosynthetic Intermediate, Rubenstein, S.M.;
Williams, R.M., J. Org. Chem., 1995, 60, 7215-7223.
84. *Synthetic
Studies on Quinocarcin: Total Synthesis of (+)-Quinocarcinamide via
Dipole Cycloaddition of an Azomethine Ylide Generated by Novel NBS Oxidation, Flanagan, M.E.;
Williams, R.M., J. Org. Chem., 1995, 60, 6791-6797.
85. *Amino
Acid Synthesis,
Williams, R.M., Molecular Biology and Biotechnology. A Comprehensive Desk
Reference, VCH,
Weinheim, Meyers, R.A., Ed., 1995, Volume 1, pp 28-33.
86. Development
of GM-CSF Antagonist Peptides, VonFeldt, J.M.; Monfardini, C.; Fish, S.;
Rosenblum, H.; Kieber-Emmons, T.; Williams, R.M.; Kahn, S.A.; Weiner, D.B.;
Williams, W.V., Pept. Res., 1995, 8, 20.
1996
87. *Amino
Acid Synthesis,
Williams, R.M., The Encyclopedia of Molecular Biology and Molecular
Medicine, VCH,
Weinheim, R.A. Meyers, Ed., 1996, Volume 1, pp 52-58.
88. *Stereocontrolled
Total Synthesis of (+)-Paraherquamide B, Cushing, T.D.; Sanz-Cervera, J.F.; Williams,
R.M., J. Am. Chem. Soc., 1996, 118, 557-579.
89. *Asymmetric
Synthesis of (2S,3S,6S)-, (2S,3S,6R)-, and
(2R,3R,6S)-2,3-Methano-2,6-diaminopimelic Acids. Studies Directed to the Design
of Novel Substrate-based Inhibitors of L,L-Diaminopimelate Epimerase, Williams, R.M.;
Fegley, G.J.; Pruess, D.L.; Schaeffer, F., Tetrahedron, 1996, 52, 1149-1164.
90. *Photochemical
Cycloaromatization Reactions of ortho-Dialkynylarenes. A New Class of DNA
Photocleaving Agents,
Funk, R.L.; Young, E.R.R.; Williams, R.M.; Flanagan, M.A.; Cecil, T.R., J.
Am. Chem. Soc.,
1996,
118,
3291-3292.
91. *An
Efficient Method for the Preparation of Amidinoureas, Williams, R.M.; Yuan,
C., Tetrahedron Lett., 1996, 37, 1945-1948.
92. *Studies
on the Biosynthesis of Paraherquamide: Origin of the b-Methylproline Ring, Stocking, E.;
Sanz-Cervera, J.F.; Williams, R.M.; Unkefer, C.J., J. Am. Chem. Soc., 1996, 118, 7008-7009.
Errata: J. Am. Chem. Soc., 1997, 119, 9588.
93. *
Studies on the Total Synthesis of Paraherquamide A. Stereocontrolled,
Asymmetric Synthesis of a-Alkyl-b-Hydroxyproline Derivatives, Williams, R.M.; Cao,
J., Tetrahedron Lett., 1996, 37, 5441-5444.
94. *Cytochrome
P-450-Catalyzed Hydroxylation of Taxa-4(5),11(12)-diene to
Taxa-4(20),11(12)-diene-5-a-ol:
The First Oxygenation Step in Taxol Biosynthesis, Hefner, J.; Rubenstein, S.M.;
Ketchum, R.E.B.; Gibson, D.M.; Williams, R.M., Croteau, R. Chem. Biol., 1996, 3, 479-489.
1997
95. *FR900482,
a Close Cousin of Mitomycin C that Exploits Mitosene-Based Cross Linking, Williams, R.M.;
Rajski, S.R.; Rollins, S.B., Chem. Biol., 1997, 4, 127-137.
96. *Biosynthesis
of the Brevianamides: A Theoretical Study of the Biosynthetic Diels-Alder
Cyclization,
Domingo, L.R.; Sanz-Cervera, J.F.; Williams, R.M.; Picher, M.T.; Marco, J.A., J.
Org. Chem., 1997, 62, 1662-1667.
97. *Synthetic
Studies on FR900482. Synthesis of a Photo-triggered Pro-Mitosene, Rollins, S.B.;
Williams, R.M., Tetrahedron Lett., 1997, 38, 4033-4036.
98. *An
Efficient Synthesis of (S)-meta-Tyrosine, Bender, D.M.; Williams, R.M., J. Org.
Chem., 1997, 62, 6690-6691.
99. *Total Sy